As an autoimmune disorder, bullous pemphigoid involves the immune system mistakenly targeting the body’s own tissues. Specifically, the immune system produces antibodies that attack proteins involved in anchoring the epidermis to the dermis. This attack weakens the bonds between these skin layers, resulting in the separation of the epidermis from the dermis and the formation of blisters. The exact cause of why the immune system initiates this attack is not fully understood, but it may involve a combination of genetic predisposition and environmental triggers, such as certain medications or infections.