Treatment for MPDs aims to manage symptoms and reduce complications, with specific strategies depending on the type of MPD:
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Phlebotomy: Regular removal of blood to reduce red blood cell mass in polycythemia vera.
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Medications: Hydroxyurea, interferon-alpha, and JAK2 inhibitors (e.g., ruxolitinib) to control blood cell production.
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Aspirin: Low-dose aspirin to reduce the risk of blood clots in patients with high platelet counts.
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Stem Cell Transplant: In cases of advanced disease or myelofibrosis, a hematopoietic stem cell transplant may be considered.
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Symptomatic Treatment: Managing symptoms like itching, night sweats, and spleen discomfort.