The prognosis for individuals with CML has significantly improved with the advent of TKIs. Many patients achieve long-term remission and have a normal or near-normal life expectancy. The chronic phase of CML can often be managed effectively for many years with proper treatment. Prognosis depends on various factors, including the patient’s response to therapy, age, overall health, and the phase of CML at diagnosis. Regular monitoring and adherence to treatment are crucial for managing the disease and maintaining a good quality of life.